Ben Lorica our man in O'Reilly Media sent me a link to this interesting Israeli company. It seems they are doing in memory and out of core computation on a single multicore machine to scale to large datasets, product some statistics which are turned into web reports. Here is their demo video:
According to their website they have some customers like ebay and NASA.
A very impressive performance is demonstrated here: 10TB of parsed data on 10 seconds on a 10,000$ server.